Structurally Well-Defined Au@Cu2- x S Core-Shell Nanocrystals for Improved Cancer Treatment Based on Enhanced Photothermal Efficiency.

Muwei Ji, Meng Xu, Wei Zhang, Zhenzhong Yang, Liu Huang, Jiajia Liu, Yong Zhang, Lin Gu, Youxing Yu, Weichang Hao, Pengfei An, Lirong Zheng, Hesun Zhu, Jiatao Zhang

Journal: Advanced materials (Deerfield Beach, Fla.) 2018;28(16):3094-101

PMID: 26913692

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Abstract

Au@Cu2- x S core-shell nanocrystals (NCs) have been synthesized under large lattice mismatch with high crystallinity, controllable shape, and nonstoichiometric composition. Both experimental observations and simulations are used to verify the flexible dual-mode plasmon coupling. The enhanced photothermal effect is harnessed for diverse HeLa cancer cell ablation applications in the NIR-I window (750-900 nm) and the NIR-II window (1000-1400 nm).

Address: Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.; Institute of Applied Physics and Computational Mathematics, Beijing, 100088, P. R. China.; Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, P. R. China.; Department of Physics, Beihang University, Beijing, 100191, P. R. China.; Beijing Synchrotron Radiation Facility (BSRF), Beijing, 100049, P. R. China.

DOI: 10.1002/adma.201503201

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https://doi.org/10.1002/adma.201503201

MeSH Terms: Copper, Crystallization, Gold, HeLa Cells, Humans, Nanomedicine, Nanoparticles, Neoplasms, Phototherapy