Brugada Syndrome.

Melvin Scheinman, Mostafa Hotait, Marwan M Refaat

Journal: Cardiac electrophysiology clinics 2016;8(1):239-45

PMID: 26920201

Full Text on Elsevier Science View on PubMed

Abstract

Brugada syndrome might stay undetected in patients until surviving cardiac arrest. Despite the prominent advances in exploring the disease in the past 2 decades, many questions remain unanswered and the controversies continue. Despite all mutations identified to be associated with the disease, two-thirds of cases have a negative genetic test. Future studies should be more directed on modulating factors and their impact on patients' risk for sudden death to help physicians in risk stratifying their patients and optimally implementing an implantable cardioverter defibrillator to prevent sudden cardiac death.

Address: Cardiac Electrophysiology, Cardiology, Department of Internal Medicine, American University of Beirut Faculty of Medicine and Medical Center, 3 Dag Hammarskjold Plaza, 8th Floor, New York, NY 10017, USA; Department of Biochemistry and Molecular Genetics, American University of Beirut Faculty of Medicine and Medical Center, 3 Dag Hammarskjold Plaza, 8th Floor, New York, NY 10017, USA; Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut, Lebanon; Cardiology Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: [email protected].; Cardiology Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.; Division of Cardiology, Department of Medicine, University of California San Francisco Medical Center, San Francisco, CA, USA.

DOI: 10.1016/j.ccep.2015.10.036

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MeSH Terms: Adult, Brugada Syndrome, Defibrillators, Implantable, Electrocardiography, Humans, Male, NAV1.5 Voltage-Gated Sodium Channel