Extrahepatic Complications of Nonalcoholic Fatty Liver Disease.

Kristina R Chacko, John Reinus

Journal: Clinics in liver disease 2017;20(2):387-401

PMID: 27063276

Full Text on Elsevier Science View on PubMed

Abstract

Nonalcoholic fatty liver disease (NAFLD) is an important cause of liver disease that is often associated with the metabolic syndrome. There is a growing awareness that extrahepatic complications occur in individuals with NAFLD, especially an increased risk of cardiovascular disease. Development of diabetes mellitus, chronic kidney disease, colorectal cancer, and endocrinopathies has been linked to NAFLD. This article reviews the extrahepatic complications affecting individuals with NAFLD and the pathogenesis underlying their development.

Address: Department of Medicine, Albert Einstein College of Medicine, 111 East 210th Street, Rosenthal 2C, Bronx, NY 10467, USA.; Department of Medicine, Albert Einstein College of Medicine, 111 East 210th Street, Rosenthal 2C, Bronx, NY 10467, USA. Electronic address: [email protected].

DOI: 10.1016/j.cld.2015.10.004

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MeSH Terms: Cardiovascular Diseases, Cholesterol Ester Storage Disease, Colorectal Neoplasms, Comorbidity, Diabetes Mellitus, Endocrine System Diseases, Humans, Non-alcoholic Fatty Liver Disease, Renal Insufficiency, Chronic, Risk Factors, Sleep Apnea, Obstructive