Cutaneous manifestations in leukemia patients.

Michael R Grunwald, Megan H McDonnell, Raghava Induru, Jonathan M Gerber

Journal: Seminars in oncology 2017;43(3):359-65

PMID: 27178689

Full Text on Elsevier Science View on PubMed

Abstract

Cutaneous complications are common in patients with leukemia. However, the cause is not always immediately clear, as there are often numerous potential etiologies. Thrombocytopenia or coagulopathy can result in ecchymoses or petechiae, whereas extramedullary (EM) involvement by leukemia can present as a rash. Leukemia can also result in skin manifestations via indirect means, including several types of paraneoplastic phenomena. Moreover, various agents routinely used to treat leukemia-most notably cytarabine (cytosine arabinoside)-can precipitate quite profound skin eruptions. Finally, infections, including fungal invasion of the skin, can be responsible for rashes, as can the vast array of antimicrobials that are administered to leukemia patients.

Address: Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC.; Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC. Electronic address: [email protected].

DOI: 10.1053/j.seminoncol.2016.02.020

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MeSH Terms: Adenine Nucleotides, Antineoplastic Agents, Arabinonucleosides, Clofarabine, Cytarabine, Dermatomycoses, Etoposide, Humans, Leukemia, Mastocytosis, Niacinamide, Paraneoplastic Syndromes, Phenylurea Compounds, Skin Diseases, Bacterial, Skin Neoplasms, Sorafenib