Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma.

Peter M Clark, Wilson X Mai, Timothy F Cloughesy, David A Nathanson

Journal: Current neurology and neuroscience reports 2016;16(2):17

PMID: 26759318

Abstract

Malignant gliomas are intractable and among the most lethal human malignancies. Like other cancers, metabolic reprogramming is a key feature of glioma and is thought to accommodate the heightened nutrient requirements for tumor cell proliferation, growth, and survival. This metabolic rewiring, driven by oncogenic signaling and molded by the unique environment of the brain, may impose vulnerabilities that could be exploited therapeutically for increased tumor control. In this review, we discuss the prominent metabolic features of malignant glioma, the key pathways regulating glioma metabolism, and the potential therapeutic opportunities for targeting metabolic processes.

Address: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA. [email protected].; Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. [email protected].; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA. [email protected].; Ahmanson Translational Imaging Division, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA. [email protected].; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA. [email protected].; Henry Singleton Brain Tumor Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA. [email protected].; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA. [email protected].; Ahmanson Translational Imaging Division, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA. [email protected].

DOI: 10.1007/s11910-015-0613-6

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https://dx.doi.org/10.1007/s11910-015-0613-6

MeSH Terms: Brain, Glioma, Humans, Signal Transduction