Thyroid side effects prophylaxis in front of nuclear power plant accidents.

Mikaël Agopiantz, Ouifak Elhanbali, Béatrice Demore, Thomas Cuny, Léa Demarquet, Cumba Ndiaye, Françoise Barbe, Laurent Brunaud, Georges Weryha, Marc Klein

Journal: Annales d'endocrinologie 2016;77(1):1-6

PMID: 26830953

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Abstract

The better knowledge of the mechanisms of nuclear incidents and lessons learned from accidents in the recent past to improve the effectiveness of measures taken following a nuclear accident exposure to fallout of radioactive iodine isotopes. Thus, immediate, passive measures, such as containment, and stopping consumption of contaminated products are paramount. The earliest possible administration of stable iodine as potassium iodide (KI) reduces significantly (up to 90% if taken at the same time of the accident) thyroid radioactive contamination. These tablets should be given in priority to children and pregnant women. The side effects are minor. KI is not recommended for persons aged over 60 years, or for adults suffering from cardiovascular disorders.

Address: University of Lorraine, Department of Endocrinology and Medical Gynecology, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France. Electronic address: [email protected].; University of Lorraine, Department of Pharmacy, 5, rue Albert-Lebrun, 54000 Nancy, France.; University of Lorraine, Department of Endocrinology and Medical Gynecology, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.; University of Lorraine, Department of Biochemistery, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.; University of Lorraine, Department of Endocrine Surgery, University Hospital of Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.

DOI: 10.1016/j.ando.2015.12.003

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MeSH Terms: Chernobyl Nuclear Accident, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Iodine Radioisotopes, Nuclear Power Plants, Potassium Iodide, Pregnancy, Radioactive Fallout, Radioactive Hazard Release, Thyroid Diseases, Thyroid Neoplasms