The potential of methylxanthine-based therapies in pediatric respiratory tract diseases.

Ainhoa Oñatibia-Astibia, Eva Martínez-Pinilla, Rafael Franco

Journal: Respiratory medicine 2016;112():1-9

PMID: 26880379

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Abstract

Caffeine, theophylline and theobromine are the most known methylxanthines as they are present in coffee, tea and/or chocolate. In the last decades, a huge experimental effort has been devoted to get insight into the variety of actions that these compounds exert in humans. From such knowledge it is known that methylxanthines have a great potential in prevention, therapy and/or management of a variety of diseases. The benefits of methylxanthine-based therapies in the apnea of prematurity and their translational potential in pediatric affections of the respiratory tract are here presented.

Address: Official College of Pharmacists of Gipuzkoa, 20006 San Sebastian, Spain. Electronic address: [email protected].; Neuroscience Department, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain. Electronic address: [email protected].; Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; CIBERNED, Centro de Investigación en Red, Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, 28049 Madrid, Spain; Institute of Biomedicine of the University of Barcelona, IBUB, 08028, Barcelona, Spain. Electronic address: [email protected].

DOI: 10.1016/j.rmed.2016.01.022

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MeSH Terms: Adolescent, Apnea, Asthma, Bronchodilator Agents, Caffeine, Child, Child, Preschool, Cough, Humans, Infant, Infant, Newborn, Infant, Premature, Phosphodiesterase Inhibitors, Theobromine, Theophylline, Xanthines