Flow-assisted basophil activation tests in immediate drug hypersensitivity: two decades of Antwerp experience.

E A Mangodt, A L Van Gasse, A Bastiaensen, I I Decuyper, A Uyttebroek, M Faber, V Sabato, C H Bridts, M M Hagendorens, L S De Clerck, D G Ebo

Journal: Acta clinica Belgica 2017;71(1):19-25

PMID: 27075810

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Abstract

The last two decades have witnessed that flow-assisted analysis of in vitro-activated basophils can constitute a valuable adjunct in the in vitro diagnostic approach of immediate drug hypersensitivity reactions (IDHR). This article summarises the current experience with the basophil activation test in the diagnosis of IDHR, with particular focus on allergy to curarising neuromuscular blocking agents, antibiotics (β-lactams and fluoroquinolones), iodinated radiocontrast media and opiates.

Address: a Faculty of Medicine and Health Science, Department of Immunology, Allergology, Rheumatology , University of Antwerp, Antwerp University Hospital , 2610 Antwerpen , Belgium.; b Faculty of Medicine and Health Science, Department of Pediatrics , University of Antwerp, Antwerp University Hospital , 2610 Antwerpen , Belgium.

DOI: 10.1080/17843286.2015.1122871