Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways.

Giulia Santinon, Arianna Pocaterra, Sirio Dupont

Journal: Trends in cell biology 2016;26(4):289-299

PMID: 26750334

Full Text on Elsevier Science View on PubMed

Abstract

Metabolism is a fundamental cellular function that can be reprogrammed by signaling pathways and oncogenes to meet cellular requirements. An emerging paradigm is that signaling and transcriptional networks can be in turn regulated by metabolism, allowing cells to coordinate their metabolism and behavior in an integrated manner. The activity of the YAP/TAZ transcriptional coactivators, downstream transducers of the Hippo cascade and powerful pro-oncogenic factors, was recently found to be regulated by metabolic pathways, such as aerobic glycolysis and mevalonate synthesis, and by the nutrient-sensing LKB1-AMPK and TSC-mTOR pathways. We discuss here current data linking YAP/TAZ to metabolism and suggest how this coupling might coordinate nutrient availability with genetic programs that sustain tissue growth, neoplastic cell proliferation, and tumor malignancy.

Address: Department of Molecular Medicine, University of Padua Medical School, Padua, Italy.; Department of Molecular Medicine, University of Padua Medical School, Padua, Italy. Electronic address: [email protected].

DOI: 10.1016/j.tcb.2015.11.004

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MeSH Terms: AMP-Activated Protein Kinase Kinases, AMP-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Calcium-Binding Proteins, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, DNA-Binding Proteins, Feedback, Physiological, Gene Expression Regulation, Neoplastic, Glycolysis, Humans, Intracellular Signaling Peptides and Proteins, Mevalonic Acid, Nuclear Proteins, Phosphoproteins, Protein Serine-Threonine Kinases, Signal Transduction, TEA Domain Transcription Factors, TOR Serine-Threonine Kinases, Trans-Activators, Transcription Factors, Transcriptional Coactivator with PDZ-Binding Motif Proteins, YAP-Signaling Proteins