Role of vitamin D in female reproduction.

Seyedeh Zahra Shahrokhi, Firouzeh Ghaffari, Faranak Kazerouni

Journal: Clinica chimica acta; international journal of clinical chemistry 2016;455():33-8

PMID: 26747961

Full Text on Elsevier Science View on PubMed

Abstract

Vitamin D is a fat-soluble vitamin that belongs to the family of steroid hormones. The biological actions of vitamin D are exerted through a soluble protein, the vitamin D receptor (VDR). VDR is a transcription factor located in the nuclei of target cells that mediates the genomic action of the active form of vitamin D (1,25(OH)2D3). This transcription factor is distributed in various tissues, including the reproductive system. The presence of VDR in female reproductive tissue suggests that vitamin D is involved in female reproduction. The present article reviews the impact of vitamin D on anti-Müllerian hormone (AMH), as an ovarian reserve marker, and ovarian steroidogenesis. This article also discusses the impact of vitamin D as a factor that influences infertility and the outcome of in vitro fertilization (IVF), insulin resistance (IR), hyperandrogenism, endometriosis and polycystic ovary syndrome (PCOS).

Address: Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.; Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.cca.2015.12.040

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MeSH Terms: Biomarkers, Female, Fertilization in Vitro, Humans, Ovary, Polycystic Ovary Syndrome, Receptors, Calcitriol, Reproduction, Vitamin D