A grain of salt on kidney dendritic cell function in allograft rejection.

Katarzyna Jobin, Christoph Heuser, Christian Kurts

Journal: Kidney international 2016;89(1):14-6

PMID: 26759039

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Abstract

Acute kidney graft allorejection affects primarily the renal cortex. The present study by Chessa et al. offers an explanation for this phenomenon. The authors employ microarray-based gene expression analysis to provide evidence that the hyperosmolarity of the renal medulla induces a transcriptional fingerprint associated with anti-inflammatory functionality in medullary dendritic cells, which may attenuate local alloreactivity. This novel immunoregulatory mechanism hints at a new opportunity to prevent allorejection.

Address: Institute of Experimental Immunology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.; Institute of Experimental Immunology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany. Electronic address: [email protected].

DOI: 10.1016/j.kint.2015.10.006

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MeSH Terms: Allografts, Dendritic Cells, Graft Rejection, Humans, Kidney, Kidney Transplantation, Sodium Chloride, Dietary