Phytochemistry and Pharmacology of Carthamus tinctorius L.

Le-Le Zhang, Ke Tian, Zheng-Hai Tang, Xiao-Jia Chen, Zhao-Xiang Bian, Yi-Tao Wang, Jin-Jian Lu

Journal: The American journal of Chinese medicine 2016;44(2):197-226

PMID: 27080938

Abstract

Carthamus tinctorius L. is a multifunctional cash crop. Its flowers and seeds are extensively used in traditional herbal medicine in China, Korea, Japan, and other Asian countries, for treating various ailments such as gynecological, cardiovascular, and cerebrovascular diseases as well as blood stasis and osteoporosis. More than 100 compounds have been isolated and identified from C. tinctorius. Flavonoids and alkaloids, especially the quinochalcone c-glycoside hydroxysafflor yellow A, N-(p-Coumaroyl)serotonin, and N-feruloylserotonin, are responsible for most of the pharmacological activities of C. tinctorius. In this paper, comprehensive and up-to-date information on the phytochemistry and pharmacology of C. tinctorius is presented. This information will be helpful for further explorations of the therapeutic potential of C. tinctorius and may provide future research opportunities.

Address: * State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.; † School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.

DOI: 10.1142/S0192415X16500130

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MeSH Terms: Alkaloids, Anti-Infective Agents, Anticoagulants, Antineoplastic Agents, Phytogenic, Antioxidants, Bone Density Conservation Agents, Cardiovascular Agents, Carthamus tinctorius, Chalcone, Flavonoids, Flowers, Humans, Phytotherapy, Plant Extracts, Quinones, Seeds, Serotonin