MR spectroscopy study of dichloroacetate treatment after ischemic stroke.

G D Graham, P B Barker, W M Brooks, D C Morris, W Ahmed, E Bryniarski, D O Hearshen, J A Sanders, B A Holshouser, C C Turkel

Journal: Neurology 2000;55(9):1376-8

PMID: 11087784

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Abstract

In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.

Address: University of New Mexico and the Albuquerque Veterans Administration Medical Center, 87108, USA. [email protected]

DOI: 10.1212/wnl.55.9.1376

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MeSH Terms: Brain Ischemia, Dichloroacetic Acid, Double-Blind Method, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Protons, Stroke