The effect of FT500 Plus(®) on ovarian stimulation in PCOS women.

Carlo Alviggi, Federica Cariati, Alessandro Conforti, Pasquale De Rosa, Roberta Vallone, Ida Strina, Rosario Pivonello, Giuseppe De Placido

Journal: Reproductive toxicology (Elmsford, N.Y.) 2016;59():40-4

PMID: 26545973

Full Text on Elsevier Science View on PubMed

Abstract

Both oxidative stress and polycystic ovary syndrome have been involved in several aspects of female reproduction. In this retrospective observational study, the outcome of controlled ovarian stimulation and follicular microenvironment of twenty-five women affected by PCOS (Group A) have been explored, evaluating the effects of myo-inositol in association with antioxidant activities (FT500 Plus(®)). Twenty-five untreated-PCOS women (Group B) with similar characteristics served as control group. Although there was no difference in ovarian volume at time zero, this parameter was significantly smaller at the 5-month follow-up in the Group A (11.1±0.9 versus 13.5±1; P=0.0001). Group A showed a significant increase in the number of MII oocytes (6.3±2.5 versus 4.5±2; P=0.03) and glutathione peroxidase activity in follicular fluid (15.4±6.2 versus 11±2.2; P=0.04). FT500 Plus(®) may be considered in PCOS patient for improving oocyte quality.

Address: Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: [email protected].; CEINGE Biotecnologie Avanzate, via G. Salvatore 486, 80145 Naples, Italy; Department of Clinical Medicine and Surgery, Endocrinology Section, University "Federico II", via Pansini 5, 80131 Naples, Italy. Electronic address: [email protected].; Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: [email protected].; Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: [email protected].; Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: [email protected].; Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: [email protected].; Department of Clinical Medicine and Surgery, Endocrinology Section, University "Federico II", via Pansini 5, 80131 Naples, Italy. Electronic address: [email protected].; Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: [email protected].

DOI: 10.1016/j.reprotox.2015.10.014

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MeSH Terms: Adult, Antioxidants, Dietary Supplements, Female, Fertility Agents, Female, Folic Acid, Follicular Fluid, Glutathione, Glutathione Peroxidase, Humans, Infertility, Female, Inositol, Oocyte Retrieval, Oocytes, Ovulation, Ovulation Induction, Oxidative Stress, Polycystic Ovary Syndrome, Pregnancy, Retrospective Studies, Treatment Outcome