Autoimmune hepatitis as a presenting manifestation of mixed connective tissue disease in a child. Case report and review of the literature.

Katarina Sedej, Nataša Toplak, Marina Praprotnik, Boštjan Luzar, Jernej Brecelj, Tadej Avčin

Journal: Pediatric rheumatology online journal 2016;13(1):47

PMID: 26554821

Abstract

BACKGROUND

Liver disease is rare in the course of mixed connective tissue disease. Most commonly liver steatosis or elevated liver function tests are reported and only a few cases of mixed connective tissue disease associated with autoimmune hepatitis were described.

CASE PRESENTATION

We report a case of an 11-year old boy with hepatitis on admission to the hospital and symptoms and signs of mixed connective tissue disease. Autoimmune hepatitis has been confirmed by liver biopsy.

CONCLUSION

To the best of our knowledge this is the youngest patient with autoimmune hepatitis as a presenting manifestation of mixed connective tissue disease.

Address: Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center, Bohoričeva 20, 1000, Ljubljana, Slovenia.; Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center, Bohoričeva 20, 1000, Ljubljana, Slovenia. [email protected].; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. [email protected].; Department of Pulmology, University Children's Hospital, University Medical Center, Ljubljana, Slovenia.; Institute of Pathology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.; Department of Gastroenterology, Hepatology and Nutrition, University Children's Hospital, Ljubljana, Slovenia.
Bant logo

© Copyright 2026, Nutrition Evidence

NED wishes to thank the following organisations for their support:

We use cookies to improve your experience and analyze site traffic with Google Analytics. By continuing to use our site, you agree to our use of cookies. Learn more.