Laboratory assessments in the course of Parkinson's disease: a clinician's perspective.

Thomas Müller, Horst Baas, Jan Kassubek, Peter Riederer, Peter Paul Urban, Christoph Schrader, Heinz Reichmann, Dirk Woitalla, Manfred Gerlach

Journal: Journal of neural transmission (Vienna, Austria : 1996) 2016;123(1):65-71

PMID: 26573521

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Abstract

Physicians, caregivers and patients themselves must be alert to the onset of and changes in motor and non-motor features during the course of Parkinson's disease (PD). Parallel laboratory routine assessments are necessary because of the evolving impairment of the general health status of the individual. A number of potential biomarkers for the diagnosis of PD are currently under investigation, with diagnosis early in the disease course a particular goal, even before the onset of motor symptoms. The aim of this guideline article is to provide user-friendly, clinical evidence-based recommendations for using laboratory pathological testing for the diagnosis and differential diagnosis of PD, for assessing its time course, and managing complications of long-term dopaminergic therapy and the disabling motor features that develop in the later stages of the disease.

Address: Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13088, Berlin, Germany. [email protected].; Department of Neurology, Klinikum Hanau GmbH, Leimenstraße 20, 63450, Hanau, Germany.; Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Füchsleinstrasse 15, 97080, Würzburg, Germany.; Department of Neurology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Germany.; Department of Neurology and Clinical Neurophysiology, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.; Department of Neurology, Technische Universität of Dresden, Fetscherstr. 74, 01307, Dresden, Germany.; Department of Neurology, Katholische Kliniken Ruhrhalbinsel GmbH, Heidbergweg 22-24, 45257, Essen, Germany.; Laboratory for Clinical Neurobiology and Therapeutic Drug Monitoring, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Würzburg, Füchsleinstrasse 15, 97080, Würzburg, Germany.

DOI: 10.1007/s00702-015-1481-6

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https://doi.org/10.1007/s00702-015-1481-6

MeSH Terms: Clinical Laboratory Techniques, Confusion, Dementia, Diagnosis, Differential, Humans, Levodopa, Parkinson Disease, Psychotic Disorders, Vitamins