Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors.

Sylvia Ganghammer, Julia Gutjahr, Evelyn Hutterer, Peter W Krenn, Susanne Pucher, Claudia Zelle-Rieser, Karin Jöhrer, Maikel Wijtmans, Rob Leurs, Martine J Smit, Valter Gattei, Richard Greil, Tanja N Hartmann

Journal: Haematologica 2017;101(3):e99-102

PMID: 26589908

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Abstract

Address: Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria Salzburg Cancer Research Institute, Austria.; Tyrolean Cancer Research Institute, Innsbruck, Austria.; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division Medicinal Chemistry, VU University Amsterdam, the Netherlands.; Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, Aviano, Italy.; Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria Salzburg Cancer Research Institute, Austria [email protected].

DOI: 10.3324/haematol.2015.133470

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https://antibodies.cancer.gov/detail/CPTC-CXCL9-2

MeSH Terms: Antineoplastic Agents, B-Lymphocytes, Chemokine CXCL10, Chemokine CXCL11, Chemokine CXCL9, Chemotaxis, Disease Progression, Gene Expression Regulation, Leukemic, Humans, Immunophenotyping, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphocyte Activation, Niacinamide, Piperazines, Predictive Value of Tests, Primary Cell Culture, Prognosis, ROC Curve, Receptor Cross-Talk, Receptors, CXCR3, Receptors, CXCR4, Signal Transduction, Survival Analysis, Treatment Outcome