Endocrine disruptors in 2015: Epigenetic transgenerational inheritance.

Michael K Skinner

Journal: Nature reviews. Endocrinology 2016;12(2):68-70

PMID: 26585656

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Abstract

Endocrine disruptors are critical environmental exposures that influence health and can promote epigenetic transgenerational inheritance of disease and abnormal physiology. Advances in 2015 included analyses of the effects of endocrine disruptors on human disease, further examples of endocrine disruptors promoting transgenerational behavioural effects, insights into effects of endocrine disruptors on epigenetic programming of primordial germ cells and the finding that endocrine disruptors can transgenerationally promote genetic mutations.

Address: Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington 99164-4236, USA.

DOI: 10.1038/nrendo.2015.206

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MeSH Terms: Diethylhexyl Phthalate, Endocrine Disruptors, Epigenesis, Genetic, Female, Gene Expression, Germ Cells, Humans, Hypospadias, Male, Mutation, Oxazoles, Pregnancy, Prenatal Exposure Delayed Effects, RNA, Untranslated, Spermatozoa