Metronomic oral vinorelbine in advanced breast cancer and non-small-cell lung cancer: current status and future development.

Marina E Cazzaniga, Andrea Camerini, Raffaele Addeo, Franco Nolè, Elisabetta Munzone, Elena Collovà, Alessandro Del Conte, Manlio Mencoboni, Paola Papaldo, Felice Pasini, Silvana Saracchini, Guido Bocci

Journal: Future oncology (London, England) 2016;12(3):373-87

PMID: 26584409

Full Text on Atypon View on PubMed

Abstract

Metronomic chemotherapy (mCT), a frequent administration of low-dose chemotherapy, allows prolonged treatment duration and minimizes the toxicity of standard-dose chemotherapy. mCT has multiple actions against cancer cells including inhibition of angiogenesis and modulation of the immune system. A number of studies lend support to the clinical efficacy of mCT in advanced breast cancer and non-small-cell lung cancer. However, further evidence is necessary to describe the optimal use of mCT and to identify suitable patients. Oral vinorelbine has emerged as a promising metronomic treatment in patients with metastatic breast cancer and non-small-cell lung cancer and is the only orally available microtubule-targeting agent. This paper reviews current evidence on metronomic oral vinorelbine, discusses its management and defines a suitable patient profile on the basis of a workshop of Italian experts.

Address: Department of Oncology, AO San Gerardo, via Pergolesi 33, 20052 Monza (MB), Italy.; Department of Medical Oncology, Versilia Hospital & Istituto Toscano Tumori, 55041 Lido di Camaiore (LU), Italy.; Oncology Unit, San Giovanni di Dio Hospital, 80027 Frattamaggiore (NA), Italy.; Division of Urogenital & Head & Neck Cancer, European Institute of Oncology, 20141 Milan, Italy.; Division of Medical Senology, European Institute of Oncology, 20141 Milan, Italy.; Oncology Unit, AO Ospedale Civile di Legnano, Legnano, 20025 Legnano (MI), Italy.; Department of Medical Oncology, Azienda per l'Assistenza Sanitaria No. 5 - Friuli Occidentale, Presidio Ospedaliero di Pordenone, 33170 Pordenone, Italy.; Oncology Unit, Villa Scassi Hospital, ASL3-Genovese, 16149 Genoa, Italy.; Department of Medical Oncology, Istituto Nazionale Tumori Regina Elena, 00144 Rome, Italy.; Department of Medical Oncology, Rovigo Hospital, ULSS18, 45100 Rovigo, Italy.; Department of Clinical & Experimental Medicine, Division of Pharmacology, University of Pisa, 56126 Pisa, Italy.

DOI: 10.2217/fon.15.306

Link outs

Free resources

Medical:

https://medlineplus.gov/breastcancer.html

Other Literature Sources:

https://scite.ai/reports/26584409

Subscription / membership required

Full Text Sources:

https://www.tandfonline.com/doi/10.2217/fon.15.306...

MeSH Terms: Administration, Metronomic, Administration, Oral, Antineoplastic Agents, Phytogenic, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Neoplasm Staging, Vinblastine, Vinorelbine