Apelin/APJ signaling in hypoxia-related diseases.

Lu He, Jin Xu, Linxi Chen, Lanfang Li

Journal: Clinica chimica acta; international journal of clinical chemistry 2016;451(Pt B):191-8

PMID: 26436483

Full Text on Elsevier Science View on PubMed

Abstract

The regulatory peptide apelin is the endogenous ligand for the orphan G protein-coupled receptor APJ. Apelin and APJ exist in a variety of tissues, with special status in the heart, lung and tumors. Consequently, the apelin/APJ system exerts a broad range of activities that affect multiple organ systems. Accumulating evidence indicates that the expressions of apelin and APJ are significantly augmented by hypoxia through the hypoxia-inducible factor-1 alpha (HIF-1α) signaling pathway. Increased apelin promotes cellular proliferation, migration and survival, therefore regulating angiogenesis. In addition, the pre-administration of exogenous apelin is involved in the occurrence and development of hypoxia-induced pathological diseases. The purpose of this article is to review the properties of the apelin/APJ system, which is affected by hypoxic conditions, and the regulation of apelin/APJ signaling in hypoxia-associated disorders. Thus, the apelin/APJ system may be a potential therapeutic target in hypoxia-related diseases.

Address: Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, University of South China, Hengyang 421001, PR China.; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, University of South China, Hengyang 421001, PR China. Electronic address: [email protected].; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, University of South China, Hengyang 421001, PR China. Electronic address: [email protected].

DOI: 10.1016/j.cca.2015.09.029

Link outs

Free resources

Medical:

https://clinicaltrials.gov/search?term=AREA%5BRefe...

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0009...

MeSH Terms: Acute Kidney Injury, Amyotrophic Lateral Sclerosis, Apelin, Apelin Receptors, Brain Ischemia, Carcinoma, Squamous Cell, Heart Failure, Humans, Hypertension, Pulmonary, Hypoxia, Intercellular Signaling Peptides and Proteins, Mouth Neoplasms, Obesity, Receptors, G-Protein-Coupled, Retinopathy of Prematurity, Signal Transduction