50 years of Arabidopsis research: highlights and future directions.

Nicholas J Provart, Jose Alonso, Sarah M Assmann, Dominique Bergmann, Siobhan M Brady, Jelena Brkljacic, John Browse, Clint Chapple, Vincent Colot, Sean Cutler, Jeff Dangl, David Ehrhardt, Joanna D Friesner, Wolf B Frommer, Erich Grotewold, Elliot Meyerowitz, Jennifer Nemhauser, Magnus Nordborg, Craig Pikaard, John Shanklin, Chris Somerville, Mark Stitt, Keiko U Torii, Jamie Waese, Doris Wagner, Peter McCourt

Journal: The New phytologist 2016;209(3):921-44

PMID: 26465351

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Abstract

922 I. 922 II. 922 III. 925 IV. 925 V. 926 VI. 927 VII. 928 VIII. 929 IX. 930 X. 931 XI. 932 XII. 933 XIII. Natural variation and genome-wide association studies 934 XIV. 934 XV. 935 XVI. 936 XVII. 937 937 References 937 SUMMARY: The year 2014 marked the 25(th) International Conference on Arabidopsis Research. In the 50 yr since the first International Conference on Arabidopsis Research, held in 1965 in Göttingen, Germany, > 54 000 papers that mention Arabidopsis thaliana in the title, abstract or keywords have been published. We present herein a citational network analysis of these papers, and touch on some of the important discoveries in plant biology that have been made in this powerful model system, and highlight how these discoveries have then had an impact in crop species. We also look to the future, highlighting some outstanding questions that can be readily addressed in Arabidopsis. Topics that are discussed include Arabidopsis reverse genetic resources, stock centers, databases and online tools, cell biology, development, hormones, plant immunity, signaling in response to abiotic stress, transporters, biosynthesis of cells walls and macromolecules such as starch and lipids, epigenetics and epigenomics, genome-wide association studies and natural variation, gene regulatory networks, modeling and systems biology, and synthetic biology.

Address: Department of Cell & Systems Biology/CAGEF, University of Toronto, Toronto, ON, M5S 3B2, Canada.; Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, 27695, USA.; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA.; Department of Biology, Stanford University, Stanford, CA, 94305, USA.; Department of Plant Biology, University of California, Davis, CA, 95616, USA.; Arabidopsis Biological Resource Center, The Ohio State University, Columbus, OH, 43210, USA.; Institute of Biological Chemistry, Washington State University, Pullman, WA, 99164, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA.; Departement de Biologie École Normale Supérieure, Biologie Moleculaire des Organismes Photosynthetiques, F-75230, Paris, France.; Department of Botany and Plant Sciences, University of California, Riverside, CA, 92507, USA.; Department of Biology and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Plant Biology, Carnegie Institution for Science, Stanford, CA, 94305, USA.; Department of Plant Biology, Agricultural Sustainability Institute, University of California, Davis, CA, 95616, USA.; Center for Applied Plant Science, The Ohio State University, Columbus, OH, 43210, USA.; Division of Biology and Biological Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA, 91125, USA.; Department of Biology, University of Washington, Seattle, WA, 98195, USA.; Gregor Mendel Institute of Molecular Plant Biology, A-1030, Vienna, Austria.; Department of Biology, Indiana University, Bloomington, IN, 47405, USA.; Biology Department, Brookhaven National Laboratory, Upton, NY, 11973, USA.; Energy Biosciences Institute, University of California, Berkeley, CA, 94704, USA.; Metabolic Networks Department, Max Planck Institute for Molecular Plant Physiology, D-14476, Potsdam, Germany.; Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.

DOI: 10.1111/nph.13687

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MeSH Terms: Arabidopsis, Epigenesis, Genetic, Plant Immunity, Research, Reverse Genetics, Signal Transduction