Immune protection-inducing protein structures (IMPIPS) against malaria: the weapons needed for beating Odysseus.

Manuel E Patarroyo, Manuel A Patarroyo, Laura Pabón, Hernando Curtidor, Luis A Poloche

Journal: Vaccine 2016;33(52):7525-37

PMID: 26469723

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Abstract

The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines. An analogy between Odysseus, the cunning hero of the epic poem Odyssey by Homer, and the elusive Plasmodium parasite has been made, to review our research group's main considerations when developing a rational methodology for designing second generation, modified peptide-based, minimal subunit, multi-antigen, multi-stage, chemically synthesised vaccines against Plasmodium falciparum malaria.

Address: Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 # 26-20, Bogotá, Colombia; Universidad Nacional de Colombia, Carrera 45 # 26-85, Bogotá, Colombia. Electronic address: [email protected].; Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 # 26-20, Bogotá, Colombia; Universidad del Rosario, Carrera 24 # 63C-69, Bogotá, Colombia.

DOI: 10.1016/j.vaccine.2015.09.109

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MeSH Terms: Amino Acid Sequence, Humans, Life Cycle Stages, Malaria Vaccines, Malaria, Falciparum, Peptides, Plasmodium falciparum, Protein Conformation, Protozoan Proteins, Vaccines, Synthetic