Can Free Water Transport Be Used as a Clinical Parameter for Peritoneal Fibrosis in Long-Term PD Patients?

Raymond T Krediet, Deirisa Lopes Barreto, Dirk G Struijk

Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2017;36(2):124-8

PMID: 26475849

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Abstract

Sodium sieving in peritoneal dialysis (PD) occurs in a situation with high osmotically-driven ultrafiltration rates. This dilutional phenomenon is caused by free water transport through the water channel aquaporin-1. It has recently been described that encapsulating peritoneal fibrosis is associated with impaired free water transport, despite normal expression of aquaporin-1. In this review, it will be argued that free water transport can be used for assessment of fibrotic peritoneal alterations, due to the water-binding capacity of collagen. Finally, the consequences for clinical practice will be discussed.

Address: Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands [email protected].; Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.; Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands Dianet Foundation, Amsterdam-Utrecht, The Netherlands.

DOI: 10.3747/pdi.2015.00129

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MeSH Terms: Biological Transport, Humans, Peritoneal Dialysis, Peritoneal Fibrosis, Peritoneum, Sodium, Water