An oral challenge test with carmine red (E120) in skin prick test positive patients.

J Liippo, K Lammintausta

Journal: European annals of allergy and clinical immunology 2016;47(6):206-10

PMID: 26549338

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Abstract

BACKGROUND

Positive skin prick test reactions to carmine red (E120) occur in approximately 3% of the patients studied for food allergy. Carmine ingestion associated systemic symptoms are occasionally suspected, but sufficient information of proven carmine allergy is not available.

PATIENTS AND METHODS

To analyse carmine related symptoms in skin prick test positive patients a cohort of 23 patients with suspected allergy to carmine red was subjected to a single-blind placebo-controlled oral challenge test with carmine red.

RESULTS

Five patients developed clinical symptoms during the placebo-controlled oral challenge. As a result, the overall frequency of clinical carmine allergy is estimated to be 0.7% in general dermatology patients studied for food-associated symptoms.

CONCLUSIONS

Oral challenge test provides a valuable in vivo tool to better inform patients with positive skin prick tests to additives to avoid false allergy diets.

Address: Department of Dermatology and Allergy Unit, Turku University Hospital and University of Turku, Hämeentie 11, P.O. Box 52, 20520 Turku, Finland. Phone: +358-2-313 1644 E-mail:[email protected].; Department of Dermatology and Allergy Unit, Turku University Hospital and University of Turku, Turku, Finland.

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Full Text Sources:

http://www.eurannallergyimm.com/cont/journals-arti...

Medical:

https://medlineplus.gov/foodallergy.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: Administration, Oral, Adult, Aged, Carmine, Female, Finland, Food Coloring Agents, Food Hypersensitivity, Humans, Intradermal Tests, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Risk Factors, Single-Blind Method, Young Adult