Beneath the Copper-Pediatric Wilson's Disease Cirrhosis and Hepatocellular Carcinoma: A Case Report with Literature Review.

Richard A Rosencrantz, Lesli LeCompte, Yasmin Yusuf

Journal: Seminars in liver disease 2016;35(4):434-8

PMID: 26676818

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Abstract

Primary hepatic malignancies are uncommon in pediatrics. Tumors such as hepatocellular carcinoma (HCC) develop typically in the setting of chronic liver disease. The incidence of HCC in Wilson's disease-related cirrhosis is disproportionately lower than in many other forms of end-stage liver disease. A preadolescent girl presented with Wilson's disease cirrhosis and a HCC requiring orthotopic liver transplantation. This case highlights the need to consider hepatic malignancies even in young Wilson's disease patients. Pediatric Wilson's disease and the hepatic tumor literature are reviewed.

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Address: Department of Pediatrics, Section of Gastroenterology and Hepatobiliary Diseases, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York.; Department of Radiology, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York.; Department of Pathology, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York.

DOI: 10.1055/s-0035-1567828

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MeSH Terms: Carcinoma, Hepatocellular, Ceruloplasmin, Child, Female, Hepatolenticular Degeneration, Humans, Liver, Liver Cirrhosis, Liver Neoplasms, Liver Transplantation, Sickle Cell Trait, Ultrasonography