The role of GATA3 in breast carcinomas: a review.

Rebecca Asch-Kendrick, Ashley Cimino-Mathews

Journal: Human pathology 2016;48():37-47

PMID: 26772397

Full Text on Elsevier Science View on PubMed

Abstract

GATA3 is a zinc-binding transcription factor that regulates the differentiation of many human tissue types, including the mammary gland. In surgical pathology, immunohistochemistry for GATA3 is largely used to support urothelial or breast origin in a carcinoma of unknown origin. GATA3 is sensitive but not entirely specific in this setting. Although GATA3 labeling is highest in estrogen receptor-positive carcinomas, it also labels estrogen receptor-negative carcinomas and thus has particular diagnostic utility in the setting of triple-negative breast carcinomas, which are typically negative for other mammary-specific markers.

Address: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231.; Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231; Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD 21231. Electronic address: [email protected].

DOI: 10.1016/j.humpath.2015.09.035

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MeSH Terms: Biomarkers, Tumor, Breast Neoplasms, Female, GATA3 Transcription Factor, Humans, Immunohistochemistry