The Nodes of Ranvier: Molecular Assembly and Maintenance.

Matthew N Rasband, Elior Peles

Journal: Cold Spring Harbor perspectives in biology 2016;8(3):a020495

PMID: 26354894

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Abstract

Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral nervous system (PNS) and central nervous system (CNS).

Address: Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.; Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.

DOI: 10.1101/cshperspect.a020495

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MeSH Terms: Action Potentials, Axons, Central Nervous System, Models, Biological, Nerve Fibers, Myelinated, Peripheral Nervous System, Ranvier's Nodes, Synaptic Transmission