Lower respiratory tract infection caused by respiratory syncytial virus: current management and new therapeutics.

Natalie I Mazur, Federico Martinón-Torres, Eugenio Baraldi, Brigitte Fauroux, Anne Greenough, Terho Heikkinen, Paolo Manzoni, Asuncion Mejias, Harish Nair, Nikolaos G Papadopoulos, Fernando P Polack, Octavio Ramilo, Mike Sharland, Renato Stein, Shabir A Madhi, Louis Bont

Journal: The Lancet. Respiratory medicine 2016;3(11):888-900

PMID: 26411809

Abstract

Respiratory syncytial virus (RSV) is a major worldwide cause of morbidity and mortality in children under five years of age. Evidence-based management guidelines suggest that there is no effective treatment for RSV lower respiratory tract infection (LRTI) and that supportive care, ie, hydration and oxygenation, remains the cornerstone of clinical management. However, RSV treatments in development in the past decade include 10 vaccines and 11 therapeutic agents in active clinical trials. Maternal vaccination is particularly relevant because the most severe disease occurs within the first 6 months of life, when children are unlikely to benefit from active immunisation. We must optimise the implementation of novel RSV therapeutics by understanding the target populations, showing safety, and striving for acceptable pricing in the context of this worldwide health problem. In this Review, we outline the limitations of RSV LRTI management, the drugs in development, and the remaining challenges related to study design, regulatory approval, and implementation.

Copyright © 2015 Elsevier Ltd. All rights reserved.

Address: Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.; Translational Pediatrics and Infectious Diseases, Pediatrics Department, Hóspital Clínico Universitario de Santiago de Compostela, University of Santiago, La Coruña, Padova, Italy.; Women's and Children's Health Department, Unit of Respiratory Medicine and Allergy, Padova, Italy.; Noninvasive ventilation and Sleep Unit, Necker Pediatric University Hospital, Paris Descartes University, Paris, France.; Division of Asthma, Allergy and Lung Biology, King's College, London, UK.; Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.; Neonataology and Neonatal Intensive Care Unit, S Anna Hospital, Torino, Italy.; Pediatric Infectious Diseases, Nationwide Children's Hospital, and The Ohio State University, Columbus, Ohio, United States of America.; Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh Medical School, Edinburgh, UK.; University of Manchester, Manchester, UK; Allergy Dept 2nd Pediatric Clinic, University of Athens, Athens, Greece.; Pediatric Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA.; Pediatric Infectious Diseases Research Group, St George's University London, UK.; Pediatric Pulmonology Unit, Pontifícia Universidade Católica RS, Porto Alegre, Brazil; Hospital for Sick Children, Toronto, Canada.; Department of Science and Technology/ National Research Foundation: Vaccine Preventable Diseases, University of Witwatersrand, Johannesburg, South Africa; Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, University of Witwatersrand, Johannesburg, South Africa.; Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands. Electronic address: [email protected].
Bant logo

© Copyright 2026, Nutrition Evidence

NED wishes to thank the following organisations for their support:

We use cookies to improve your experience and analyze site traffic with Google Analytics. By continuing to use our site, you agree to our use of cookies. Learn more.