Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis.

Address: Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Trousseau, Pediatric Pulmonary Department; Institut National de la Santé et la Recherche Médicale (INSERM) U938, Paris 75012, France.; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris 06, Paris 75005, France.; Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; AP-HP, Hôpital St Antoine, Biostatistics Department; Inserm U1136, Paris 75012, France.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Marsico Lung Institute/UNC CF Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Anschutz Medical Center, Aurora, Colorado 80045, USA.; Children's Hospital Colorado, Anschutz Medical Center, Aurora, Colorado 80045, USA.; Department of Pediatrics, School of Medicine, Anschutz Medical Center, Aurora, Colorado 80045, USA.; Division of Pediatric Pulmonology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 0A4.; Program in Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 0A4.; Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3G3.; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada M5T 3M7.; Bioinformatics Research Center and Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695, USA.; Division of Pulmonary Medicine, Department of Pediatrics, Stanley Manne Research Institute, Northwestern University Feinberg School of Medicine, Ann and Robert Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA.; Department of Pediatrics, University of Toronto, Toronto, Ontario M5G 1X8, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.; Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.; Bioinformatics Research Center and Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695, USA.; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.