Pregnancy and Thoracic Aortic Disease: Managing the Risks.

Shaynah Wanga, Candice Silversides, Annie Dore, Vivian de Waard, Barbara Mulder

Journal: The Canadian journal of cardiology 2016;32(1):78-85

PMID: 26604124

Full Text on Elsevier Science View on PubMed

Abstract

The most common aortopathies in women of childbearing age are bicuspid aortic valve, coarctation of the aorta, Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome, SMAD3 aortopathy, Turner syndrome, and familial thoracic aneurysm and dissection. The hemodynamic and hormonal changes of pregnancy increase the risk of progressive dilatation or dissection of the aorta in these women. The presence of hypertension increases the risk further. Therefore, appropriate preconception counselling is advised. For women who become pregnant, serial follow-up by a specialized multidisciplinary team throughout pregnancy and postpartum period is required. In this review we discuss risk assessment and management strategies for women with aortopathies.

Address: Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands; Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands.; Division of Cardiology, Department of Medicine, Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.; Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.; Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands.; Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands. Electronic address: [email protected].

DOI: 10.1016/j.cjca.2015.09.003

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MeSH Terms: Aorta, Thoracic, Aortic Diseases, Disease Management, Female, Humans, Pregnancy, Pregnancy Complications, Cardiovascular