The Role of Systemic Retinoids in the Treatment of Cutaneous T-Cell Lymphoma.

Auris O Huen, Ellen J Kim

Journal: Dermatologic clinics 2016;33(4):715-29

PMID: 26433844

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Abstract

Retinoids are natural and synthetic vitamin A analogs with effects on cell proliferation, differentiation, and apoptosis. They have significant activity in hematologic malignancies and have been studied extensively in cutaneous T-cell lymphoma. Retinoids bind to nuclear receptors and exert their effects through moderation of gene expression. Retinoic acid receptor and retinoic X receptor exert regulatory activity in vivo, binding to distinct ligands. Studies investigating systemic retinoids as monotherapy and in combination with other agents active against cutaneous lymphoma are reviewed. Side effects associated with retinoids include teratogenicity, dyslipidemias, and hypothyroidism, which should be carefully monitored in patients receiving treatment.

Address: Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Suite 330S, Philadelphia, PA 19104, USA.; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Suite 330S, Philadelphia, PA 19104, USA. Electronic address: [email protected].

DOI: 10.1016/j.det.2015.05.007

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MeSH Terms: Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Bexarotene, Combined Modality Therapy, Humans, Hyperlipidemias, Hypothyroidism, Immunologic Factors, Interferons, Mycosis Fungoides, PUVA Therapy, Retinoids, Sezary Syndrome, Skin Neoplasms, Tetrahydronaphthalenes