Clinical Applications of Myocardial Innervation Imaging.

Mark I Travin

Journal: Cardiology clinics 2016;34(1):133-47

PMID: 26590785

Full Text on Elsevier Science View on PubMed

Abstract

Cardiac autonomic innervation plays an important role in regulating function. Adrenergic innervation imaging is possible with the norepinephrine analogue radiotracer iodine 123 meta-iodobenzylguanidine ((123)I-mIBG) and positron emitting tracers such carbon-11 hydroxyephedrine. (123)I-mIBG uptake is assessed globally via the heart to mediastinum ratio on planar images and regionally with tomographic imaging and has utility in various cardiac diseases. There is promise for guiding expensive invasive therapies such as implantable defibrillators, ventricular assist devices, and transplant. There are reports of utility in primary arrhythmic conditions, ischemic heart disease, and diabetes and after cardiac damaging chemotherapy.

Address: Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center, 111 East-210th Street, Bronx, NY 10467-2490, USA. Electronic address: [email protected].

DOI: 10.1016/j.ccl.2015.06.003

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MeSH Terms: 3-Iodobenzylguanidine, Cardiac Imaging Techniques, Heart, Heart Failure, Humans, Positron-Emission Tomography, Radiopharmaceuticals