Understanding the genetic architectonics of complex CNS traits: Lost by the association, but found in the interaction?

Adam Michael Stewart, Michael Nguyen, Cai Song, Allan V Kalueff

Journal: Journal of psychopharmacology (Oxford, England) 2016;29(8):872-7

PMID: 26156859

Abstract

Recent evidence supports the value of endophenotypes and genome-wide association studies in psychiatric genetics, and their importance for dissecting the neural pathways and molecular mechanisms of complex neuropsychiatric disorders. Continuing this important discussion, here we outline three new mechanisms by which novel classes of genes may facilitate CNS pathogenesis without directly worsening its individual 'established' endophenotypes. These putative genetic mechanisms can apply to other human disorders in general, and may also be used for designing novel effective CNS drug treatments.

Address: ZENEREI Institute, Slidell, LA, USA.; ZENEREI Institute, Slidell, LA, USA Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.; Research Institute for Marine Drugs and Nutrition, College for Food Science and Technology, Guangdong Ocean University, Zhanjiang, China Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada.; ZENEREI Institute, Slidell, LA, USA Research Institute for Marine Drugs and Nutrition, College for Food Science and Technology, Guangdong Ocean University, Zhanjiang, China Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia [email protected].

DOI: 10.1177/0269881115593904

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MeSH Terms: Central Nervous System Diseases, Endophenotypes, Genetic Predisposition to Disease, Humans