NTCP opens the door for hepatitis B virus infection.

Huan Yan, Yang Liu, Jianhua Sui, Wenhui Li

Journal: Antiviral research 2016;121():24-30

PMID: 26071008

Full Text on Elsevier Science View on PubMed

Abstract

A liver bile acids transporter, sodium taurocholate cotransporting polypeptide (NTCP, encoded by SLC10A1) was recently identified as a functional receptor for hepatitis B virus (HBV) and its satellite hepatitis D virus (HDV). NTCP-complemented human hepatoma HepG2 cells (HepG2-NTCP) were shown to support infection of HBV and HDV in vitro, providing a much-needed and convenient cell culture system for the viruses. Identification of NTCP as a functional receptor for HBV has significantly advanced our understanding of the viral life cycle and opened new opportunities for developing anti-HBV interventions. This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B".

Address: National Institute of Biological Sciences, Beijing 102206, China; Postdoctoral Program, Peking University, Beijing 100871, China.; National Institute of Biological Sciences, Beijing 102206, China; Graduate Program, Tsinghua University, Beijing 100084, China.; National Institute of Biological Sciences, Beijing 102206, China.; National Institute of Biological Sciences, Beijing 102206, China. Electronic address: [email protected].

DOI: 10.1016/j.antiviral.2015.06.002

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MeSH Terms: Hep G2 Cells, Hepatitis B virus, Hepatitis Delta Virus, Hepatocytes, Humans, Organic Anion Transporters, Sodium-Dependent, Receptors, Virus, Symporters, Virus Internalization