Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes.

Ioannis Karakikes, Mohamed Ameen, Vittavat Termglinchan, Joseph C Wu

Journal: Circulation research 2015;117(1):80-8

PMID: 26089365

Abstract

Disease models are essential for understanding cardiovascular disease pathogenesis and developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology has generated significant enthusiasm for its potential application in basic and translational cardiac research. Patient-specific iPSC-derived cardiomyocytes offer an attractive experimental platform to model cardiovascular diseases, study the earliest stages of human development, accelerate predictive drug toxicology tests, and advance potential regenerative therapies. Harnessing the power of iPSC-derived cardiomyocytes could eliminate confounding species-specific and interpersonal variations and ultimately pave the way for the development of personalized medicine for cardiovascular diseases. However, the predictive power of iPSC-derived cardiomyocytes as a valuable model is contingent on comprehensive and rigorous molecular and functional characterization.

Address: From the Stanford Cardiovascular Institute (I.K., M.A., V.T., J.C.W.), Department of Medicine, Division of Cardiovascular Medicine (I.K., V.T., J.C.W.), and Institute of Stem Cell Biology and Regenerative Medicine (J.C.W.), Stanford University School of Medicine, CA. [email protected] [email protected].; From the Stanford Cardiovascular Institute (I.K., M.A., V.T., J.C.W.), Department of Medicine, Division of Cardiovascular Medicine (I.K., V.T., J.C.W.), and Institute of Stem Cell Biology and Regenerative Medicine (J.C.W.), Stanford University School of Medicine, CA.

DOI: 10.1161/CIRCRESAHA.117.305365

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MeSH Terms: Action Potentials, Bioengineering, Calcium Signaling, Cardiovascular Diseases, Cations, Cell Culture Techniques, Cell Differentiation, Cell Lineage, Drug Evaluation, Preclinical, Electrophysiology, Energy Metabolism, Excitation Contraction Coupling, Fetal Heart, Gene Expression Profiling, Humans, Induced Pluripotent Stem Cells, Ion Channels, Myocardial Contraction, Myocytes, Cardiac, Phenotype