Cutaneous Manifestations of Crohn Disease.

Joshua W Hagen, Jason M Swoger, Lisa M Grandinetti

Journal: Dermatologic clinics 2016;33(3):417-31

PMID: 26143422

Full Text on Elsevier Science View on PubMed

Abstract

Awareness of the extraintestinal manifestations of Crohn disease is increasing in dermatology and gastroenterology, with enhanced identification of entities that range from granulomatous diseases recapitulating the underlying inflammatory bowel disease to reactive conditions and associated dermatoses. In this review, the underlying etiopathology of Crohn disease is discussed, and how this mirrors certain skin manifestations that present in a subset of patients is explored. The array of extraintestinal manifestations that do not share a similar pathology, but which are often seen in association with inflammatory bowel disease, is also discussed. Treatment and pathogenetic mechanisms, where available, are discussed.

Address: Department of Dermatology, University of Pittsburgh Medical Center, Medical Arts Building, 3708 Fifth Avenue, 5th Floor, Pittsburgh, PA 15213, USA.; Department of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, 200 Lothrop street, C-Wing, Mezzanine, Pittsburgh, PA 15213, USA.; Department of Dermatology, University of Pittsburgh Medical Center, Medical Arts Building, 3708 Fifth Avenue, 5th Floor, Pittsburgh, PA 15213, USA. Electronic address: [email protected].

DOI: 10.1016/j.det.2015.03.007

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MeSH Terms: Crohn Disease, Erythema Nodosum, Granulomatosis, Orofacial, Humans, Lymphedema, Pyoderma Gangrenosum, Skin Diseases, Sweet Syndrome, Vasculitis, Leukocytoclastic, Cutaneous