Granulomatous Drug Eruptions.

Roni P Dodiuk-Gad, Neil H Shear

Journal: Dermatologic clinics 2016;33(3):525-39

PMID: 26143430

Full Text on Elsevier Science View on PubMed

Abstract

Granuloma formation is usually regarded as a means of defending the host from persistent irritants of either exogenous or endogenous origin. Noninfectious granulomatous disorders of the skin encompass a challenging group of diseases owing to their clinical and histologic overlap. Drug reactions characterized by a granulomatous reaction pattern are rare, and defined by a predominance of histiocytes in the inflammatory infiltrate. This review summarizes current knowledge on the various types of granulomatous drug eruptions, focusing on the 4 major types: interstitial granulomatous drug reaction, drug-induced accelerated rheumatoid nodulosis, drug-induced granuloma annulare, and drug-induced sarcoidosis.

Address: Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room M1-737, Toronto, ON M4N 3M5, Canada; Department of Dermatology, Ha'emek Medical Center, Afula 18101, Israel.; Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room M1-737, Toronto, ON M4N 3M5, Canada; Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Room M1-737, Toronto, Ontario M4N 3M5, Canada. Electronic address: [email protected].

DOI: 10.1016/j.det.2015.03.015

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MeSH Terms: Antirheumatic Agents, Antiviral Agents, Calcium Channel Blockers, Drug Eruptions, Granuloma, Granuloma Annulare, Humans, Interferon-alpha, Rheumatoid Nodule, Sarcoidosis