Deep Fungal Infections, Blastomycosis-Like Pyoderma, and Granulomatous Sexually Transmitted Infections.

Jacqueline A Guidry, Christopher Downing, Stephen K Tyring

Journal: Dermatologic clinics 2016;33(3):595-607

PMID: 26143434

Full Text on Elsevier Science View on PubMed

Abstract

Granulomatous diseases are caused by multiple infectious and noninfectious causes. Deep fungal infections can present in the skin or extracutaneously, most commonly with lung manifestations. An Azole or amphotericin B is the universal treatment. Blastomycosis-like pyoderma is a clinically similar condition, which is caused by a combination of hypersensitivity and immunosuppression. Successful treatment has been reported with antibiotics and, more recently, the vitamin A analog, acitretin. Granuloma inguinale and lymphogranuloma venereum cause ulcerative genital lesions with a granulomatous appearance on histology. The Centers for Disease Control and Prevention recommens treatment of these genital infections with doxycycline.

Address: Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA.; Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA. Electronic address: [email protected].; Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA; Department of Dermatology, University of Texas Health Science Center, 6655 Travis, Suite 600, Houston, TX 77003, USA.

DOI: 10.1016/j.det.2015.03.019

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MeSH Terms: Acitretin, Amphotericin B, Anti-Bacterial Agents, Antifungal Agents, Azoles, Blastomycosis, Coccidioidomycosis, Cryptococcosis, Dermatomycoses, Doxycycline, Granuloma Inguinale, Histoplasmosis, Humans, Keratolytic Agents, Lymphogranuloma Venereum, Mycoses, Pyoderma, Sexually Transmitted Diseases, Sporotrichosis