Enzymatic synthesis and characterization of galactosyl monoesters.

Dong An, Xiaohui Zhao, Zhiwen Ye

Journal: Carbohydrate research 2016;414():32-8

PMID: 26172090

Full Text on Elsevier Science View on PubMed

Abstract

Enzyme-catalyzed synthesis of several fatty acyl-amino acid esters based on D-galactose, as well as their chemical evaluation, was performed. These novel galactosyl fatty acyl-amino acid monoesters were synthesized by utilizing lipase from lipozyme TL IM in tert-butanol with D-galactose and fatty acyl-amino acids as starting materials. The products were characterized by (1)H NMR, (13)C NMR and MS analysis. In addition, their primary physical properties, such as hydrophilic-lipophilic balance (HLB), critical micellar concentration (CMC), solubility in water, maximum surface excess (Γmax), and minimal surface tension (Amin) were measured. The experimental results showed that their CMC values are between 5 and 0.4 mM. The HLB values of galactosyl esters 15-17 indicate that they are useful as oil-in-water emulsions or detergents, whereas 18-22 can be employed as water-in-oil emulsifiers or wetting agents.

Address: Department of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, People's Republic of China.; Department of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, People's Republic of China. Electronic address: [email protected].

DOI: 10.1016/j.carres.2015.05.011

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MeSH Terms: Butanols, Esters, Fatty Acids, Galactose, Lipase, Magnetic Resonance Spectroscopy, Molecular Structure, Solubility, Surface Tension