Interaction of syntaxins with epithelial ion channels.

S Saxena, M W Quick, D G Warnock

Journal: Current opinion in nephrology and hypertension 2001;9(5):523-7

PMID: 10990372

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Abstract

Recent evidence suggests that some of the syntaxin isoforms may physically interact with and regulate the transport activity of a defined set of membrane transport proteins. This review examines recent studies of the cystic fibrosis transmembrane conductance regulator and the epithelial sodium channel which define distinct roles of syntaxin 1A and syntaxin 3 in the regulation of surface expression as well as intrinsic properties of these epithelial ion transporters.

Address: Nephrology Research and Training Center, Department of Medicine, University of Alabama at Birmingham, USA.

DOI: 10.1097/00041552-200009000-00011

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MeSH Terms: Cystic Fibrosis Transmembrane Conductance Regulator, Epithelial Sodium Channels, Humans, Membrane Proteins, Qa-SNARE Proteins, SNARE Proteins, Sodium Channels, Syntaxin 1, Vesicular Transport Proteins