Kinetics and Immunodominance of Virus-Specific T Cell Responses During Hantaan Virus Infection.

Meiliang Wang, Jiuping Wang, Zhenhua Kang, Qiuling Zhao, Xiaohui Wang, Ling Hui

Journal: Viral immunology 2016;28(5):265-71

PMID: 25945718

Abstract

Immunodominant T cell responses are important for protection against virus challenge. However, studies screening for the immunodominant T cell responses and following their kinetics in acute Hantaan virus (HTNV) infection are very limited. Herein, the HTNV nucleocapsid protein-specific T cell responses were longitudinally screened in 15 patients with acute HTNV infection, eight of whom had a particularly severe hemorrhagic fever with renal syndrome (HFRS). An extremely impaired IFN-γ-producing T cell response was observed in patients with severe HFRS at the early stage of infection, especially to the immunodominant epitopes detected in the mild to moderate group, namely peptides N127-141, N139-153, N241-255, and N355-369. The initially insufficient T cell response to the immunodominant epitopes may play a role in influencing the severity of HTNV infection. These findings provide information that may aid the design of future vaccines against hantaviruses.

Address: 1Center for Experimental Medicine, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou, China.; 2Department of Infectious Diseases, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.; 3Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Changchun, China.; 4Department of Nutriment, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou, China.; 1Center for Experimental Medicine, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou, China.; 5Gansu Key Laboratory of Stem Cell and Gene Therapy, Lanzhou, China.

DOI: 10.1089/vim.2014.0135

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MeSH Terms: Adult, Aged, CD8-Positive T-Lymphocytes, Capsid Proteins, Epitopes, T-Lymphocyte, Female, Hantaan virus, Hantavirus Infections, Hemorrhagic Fever with Renal Syndrome, Humans, Immunodominant Epitopes, Interferon-gamma, Male, Middle Aged, Viral Core Proteins, Young Adult