Dysbiosis and Immune Dysregulation in Outer Space.

Jorge L Cervantes, Bo-Young Hong

Journal: International reviews of immunology 2016;35(1):67-82

PMID: 25970037

Abstract

In space, the lifestyle, relative sterility of spaceship and extreme environmental stresses, such as microgravity and cosmic radiation, can compromise the balance between human body and human microbiome. An astronaut's body during spaceflight encounters increased risk for microbial infections and conditions because of immune dysregulation and altered microbiome, i.e. dysbiosis. This risk is further heightened by increase in virulence of pathogens in microgravity. Health status of astronauts might potentially benefit from maintaining a healthy microbiome by specifically managing their diet on space in addition to probiotic therapies. This review focuses on the current knowledge/understanding of how spaceflight affects human immunity and microbiome.

Address: a Department of Pediatrics, University of Connecticut Health Center , Farmington , CT , USA .; b Division of Periodontology, Department of Oral Health and Diagnostic Sciences , University of Connecticut Health Center , Farmington , CT , USA.

DOI: 10.3109/08830185.2015.1027821

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MeSH Terms: Astronauts, Bacteroides, Candida albicans, Clostridiales, Clostridioides difficile, Cosmic Radiation, Cytokines, Dendritic Cells, Dietary Supplements, Dysbiosis, Escherichia coli, Gastrointestinal Microbiome, Helicobacter hepaticus, Humans, Immunity, Leukocytes, Probiotics, Pseudomonas aeruginosa, Salmonella typhimurium, Space Flight, Virulence, Weightlessness