Molecular Interactions of β-(1→3)-Glucans with Their Receptors.

Laurent Legentil, Franck Paris, Caroline Ballet, Sophie Trouvelot, Xavier Daire, Vaclav Vetvicka, Vincent Ferrières

Journal: Molecules (Basel, Switzerland) 2016;20(6):9745-66

PMID: 26023937

Abstract

β-(1→3)-Glucans can be found as structural polysaccharides in cereals, in algae or as exo-polysaccharides secreted on the surfaces of mushrooms or fungi. Research has now established that β-(1→3)-glucans can trigger different immune responses and act as efficient immunostimulating agents. They constitute prevalent sources of carbons for microorganisms after subsequent recognition by digesting enzymes. Nevertheless, mechanisms associated with both roles are not yet clearly understood. This review focuses on the variety of elucidated molecular interactions that involve these natural or synthetic polysaccharides and their receptors, i.e., Dectin-1, CR3, glycolipids, langerin and carbohydrate-binding modules.

Address: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. [email protected].; Université européenne de Bretagne, F-35000 Rennes, France. [email protected].; Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. [email protected].; Université européenne de Bretagne, F-35000 Rennes, France. [email protected].; Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. [email protected].; Université européenne de Bretagne, F-35000 Rennes, France. [email protected].; INRA, UMR AgroSup/INRA/uB 1347 Agroécologie, Pôle Interactions Plantes-Microorganismes-ERL CNRS 6300, 21065 Dijon Cedex, France. [email protected].; INRA, UMR AgroSup/INRA/uB 1347 Agroécologie, Pôle Interactions Plantes-Microorganismes-ERL CNRS 6300, 21065 Dijon Cedex, France. [email protected].; Department of Pathology, University of Louisville, Louisville, KY 40202, USA. [email protected].; Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. [email protected].; Université européenne de Bretagne, F-35000 Rennes, France. [email protected].

DOI: 10.3390/molecules20069745

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MeSH Terms: Adjuvants, Immunologic, Agaricales, Antigens, CD, Edible Grain, Gene Expression Regulation, Glucan 1,3-beta-Glucosidase, Glycolipids, Humans, Lectins, C-Type, Macrophage-1 Antigen, Mannose-Binding Lectins, Receptors, Scavenger, Signal Transduction, Stramenopiles, beta-Glucans