Aerosol Medications for Treatment of Mucus Clearance Disorders.

Bruce K Rubin

Journal: Respiratory care 2016;60(6):825-9; discussion 830-32

PMID: 26070577

Abstract

Airway mucus hypersecretion and secretion retention can result from inflammation, irritation, stimulation, or mucus-producing tumors. Secretion clearance can be furthered hampered by ciliary dysfunction and by weakness or restrictive lung disease, leading to an ineffective cough. There are a number of different mucoactive medications that have been used to reduce hypersecretion, make secretions easier to transport, or increase the efficiency of cough or mucus clearance. In this paper, I review the pathophysiology of secretory hyper-responsiveness and mucus hypersecretion and discuss the different aerosol medications that can be used to augment secretion clearance.

Address: Department of Pediatrics, Virginia Commonwealth University School of Medicine, and the Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia. [email protected].

DOI: 10.4187/respcare.04087

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MeSH Terms: Administration, Inhalation, Aerosols, Cough, Expectorants, Humans, Lung Diseases, Mucociliary Clearance, Mucus