Granuloma Annulare.

Emily Louise Keimig

Journal: Dermatologic clinics 2016;33(3):315-29

PMID: 26143416

Full Text on Elsevier Science View on PubMed

Abstract

Granuloma annulare (GA) is a noninfectious granulomatous skin condition that can present with a variety of cutaneous morphologies. It is characterized by collagen degeneration, mucin deposition, and palisaded or interstitial histiocytes. Although the mechanism underlying development of GA is unknown, studies point to a cell-mediated hypersensitivity reaction to an as-yet undetermined antigen. Systemic associations with diabetes, thyroid disorders, lipid abnormalities, malignancy, and infection are described in atypical GA. Treatment is divided into localized skin-directed therapies and systemic immunomodulatory or immunosuppressive therapies. The selected treatment modality should be based on disease severity, comorbid conditions, consideration of potential side effects, and patient preference.

Address: Department of Dermatology, Northwestern University, 676 North St Clair, Suite 1600, Chicago, IL 60611, USA. Electronic address: [email protected].

DOI: 10.1016/j.det.2015.03.001

Link outs

Subscription / membership required

Full Text Sources:

MeSH Terms: Antimalarials, Complement C3, Diabetes Mellitus, Granuloma Annulare, Humans, Hyperlipidemias, Immunoglobulin M, Immunosuppressive Agents, Interferon-gamma, Interleukin-12, Neoplasms, Photochemotherapy, Retinoids, Skin, T-Lymphocytes, Tetracyclines, Th1 Cells, Thyroid Diseases, Tumor Necrosis Factor-alpha, Ultraviolet Therapy