The effects of salicylate on bacteria.

C T Price, I R Lee, J E Gustafson

Journal: The international journal of biochemistry & cell biology 2000;32(10):1029-43

PMID: 11091136

Full Text on Elsevier Science View on PubMed

Abstract

Salicylate and related compounds, such as aspirin, have a variety of effects in eucaryotic systems and are well known for their medicinal properties. Salicylate also has numerous effects on bacteria, yet only a handful of individuals within the scientific community appreciate these findings. From a bacterial viewpoint, growth in the presence of salicylate can be both beneficial and detrimental. On one hand, growth of certain bacteria in the presence of salicylate can induce an intrinsic multiple antibiotic resistance phenotype. On the other hand, growth in the presence of salicylate can reduce the resistance to some antibiotics and affect virulence factor production in some bacteria. This review provides an overview of the effects salicylate has on various bacterial species.

Address: Microbiology and Biochemistry Groups, School of Biomedical Sciences, Curtin University of Technology, Perth 6845, WA, Australia.

DOI: 10.1016/s1357-2725(00)00042-x

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MeSH Terms: Amino Acid Sequence, Bacteria, Bacterial Proteins, Biological Transport, Carrier Proteins, Drug Resistance, Microbial, Escherichia coli Proteins, Eukaryotic Cells, Fusidic Acid, Humans, Membrane Proteins, Molecular Sequence Data, Multidrug Resistance-Associated Proteins, Salicylates, Sequence Alignment, Virulence