The Potential for Plant Derivatives against Acrylamide Neurotoxicity.

O O Adewale, J M Brimson, O A Odunola, M A Gbadegesin, S E Owumi, C Isidoro, T Tencomnao

Journal: Phytotherapy research : PTR 2015;29(7):978-85

PMID: 25886076

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Abstract

Certain industrial chemicals and food contaminants have been demonstrated to possess neurotoxic activity and have been suspected to cause brain-related disorders in humans. Acrylamide (ACR), a confirmed neurotoxicant, can be found in trace amount in commonly consumed human aliments as a result of food processing or cooking. This discovery aroused a great concern in the public, and increasing efforts are continuously geared towards the resolution of this serious threat. The broad chemical diversity of plants may offer the resources for novel antidotes against neurotoxicants. With the goal of attenuating neurotoxicity of ACR, several plants extracts or derivatives have been employed. This review presents the plants and their derivatives that have been shown most active against ACR-induced neurotoxicity, with a focus on their origin, pharmacological activity, and antidote effects.

Address: Cancer Research and Molecular Biology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Chemical Sciences, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria.; Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.; Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.; Cancer Research and Molecular Biology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', Novara, Italy.

DOI: 10.1002/ptr.5353

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MeSH Terms: Acorus, Acrylamide, Acyclic Monoterpenes, Curcuma, Disulfides, Flavonoids, Zingiber officinale, Humans, Monoterpenes, Neuroprotective Agents, Neurotoxicity Syndromes, Panax, Phytochemicals, Phytotherapy, Rosmarinus, Rutin, Soy Foods, Sulfinic Acids