How do voltage-gated sodium channels enhance migration and invasiveness in cancer cells?

Pierre Besson, Virginie Driffort, Émeline Bon, Frédéric Gradek, Stéphan Chevalier, Sébastien Roger

Journal: Biochimica et biophysica acta 2015;1848(10 Pt B):2493-501

PMID: 25922224

Free Full Text on Elsevier Science View on PubMed

Abstract

Voltage-gated sodium channels are abnormally expressed in tumors, often as neonatal isoforms, while they are not expressed, or only at a low level, in the matching normal tissue. The level of their expression and their activity is related to the aggressiveness of the disease and to the formation of metastases. A vast knowledge on the regulation of their expression and functioning has been accumulated in normal excitable cells. This helped understand their regulation in cancer cells. However, how voltage-gated sodium channels impose a pro-metastatic behavior to cancer cells is much less documented. This aspect will be addressed in the review. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.

Address: Inserm UMR1069 "Nutrition, Croissance et Cancer", Faculté de Médecine, Université François Rabelais de Tours, France; Faculté de Sciences Pharmaceutiques, Université François Rabelais de Tours, France. Electronic address: [email protected].; Inserm UMR1069 "Nutrition, Croissance et Cancer", Faculté de Médecine, Université François Rabelais de Tours, France.; Inserm UMR1069 "Nutrition, Croissance et Cancer", Faculté de Médecine, Université François Rabelais de Tours, France; Faculté de Sciences Pharmaceutiques, Université François Rabelais de Tours, France.; Inserm UMR1069 "Nutrition, Croissance et Cancer", Faculté de Médecine, Université François Rabelais de Tours, France; Faculté des Sciences et Techniques, Université François Rabelais de Tours, France.

DOI: 10.1016/j.bbamem.2015.04.013

Link outs

Free resources

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0005...

MeSH Terms: A Kinase Anchor Proteins, Adaptor Proteins, Signal Transducing, Cell Movement, GPI-Linked Proteins, Gene Expression Regulation, Neoplastic, Humans, Membrane Potentials, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Signal Transduction, Sodium, Tumor Microenvironment, Voltage-Gated Sodium Channels