Relation between plasmatic and cerebrospinal fluid oxidative stress biomarkers and intrathecal Ig synthesis in Multiple Sclerosis patients.

Livia Pasquali, Chiara Pecori, Lucia Chico, Alfonso Iudice, Gabriele Siciliano, Ubaldo Bonuccelli

Journal: Journal of neuroimmunology 2015;283():39-42

PMID: 26004154

Full Text on Elsevier Science View on PubMed

Abstract

The aim of this study was to evaluate if cerebrospinal fluid (CSF) oxidative stress biomarkers were related to plasmatic levels and to intrathecal Ig synthesis in 51 patients with Multiple Sclerosis (MS) or clinically isolated syndrome (CIS). Plasmatic and CSF ferric reducing ability (FRA) showed a significant positive correlation (ρ 0.28, p=0.04), while advanced oxidation protein products (AOPPs) did not. A negative correlation was found between IgG synthesis index and CSF FRA levels. No difference in CSF AOPPs or FRA was observed between patients with and without intrathecal IgM synthesis. Our results indicate that plasmatic and CSF FRA are strictly linked, while CSF oxidative stress biomarkers are not related to intrathecal Ig synthesis.

Address: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: [email protected].; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy; Azienda ULSS 12 "Veneziana", dell'Angelo Hospital, Neurology Unit, Via Paccagnella 11, 30174 Mestre (Venice), Italy. Electronic address: [email protected].; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: [email protected].; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: [email protected].; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: [email protected].; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: [email protected].

DOI: 10.1016/j.jneuroim.2015.04.010

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MeSH Terms: Adolescent, Adult, Advanced Oxidation Protein Products, Aged, B-Lymphocytes, Biomarkers, Chlorides, Female, Ferric Compounds, Humans, Immunoglobulin M, Immunoglobulins, Male, Middle Aged, Multiple Sclerosis, Oxidation-Reduction, Oxidative Stress, Subarachnoid Space, Young Adult