Recent developments in the trifluoromethylation of alkynes.

Pin Gao, Xian-Rong Song, Xue-Yuan Liu, Yong-Min Liang

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 2016;21(21):7648-61

PMID: 25737368

Abstract

In the last few years, the development of versatile methodologies to incorporate trifluoromethyl groups into organic molecules has attracted significant attention in synthetic chemistry. This review gives an overview over the development on the trifluoromethylation of alkynes, which have not been solely discussed before. Formation of diverse C(sp, sp(2) , sp(3) )-CF3 bonds are all covered in this review.

Address: State key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (China), Fax: (+86) 931-891-2582.

DOI: 10.1002/chem.201406432

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https://doi.org/10.1002/chem.201406432

MeSH Terms: Alkynes, Chemistry Techniques, Synthetic, Halogenation, Hydrocarbons, Fluorinated, Methylation